Inflammatory bowel disease is linked to 19p13 and associated with ICAM-1

Low, Jin Hong, Williams, Fiona A., Yang, Xuesong, Cullen, Sue, Colley, James, Ling, Khoon Lin, Armuzzi, Alessandro, Ahmad, Tariq, Neville, Matt J., Dechairo, Bryan M., Walton, Robert, Lench, Nick J. and Jewell, Derek P. 2004. Inflammatory bowel disease is linked to 19p13 and associated with ICAM-1. Inflammatory Bowel Diseases 10 (3) , pp. 173-181. 10.1097/00054725-200405000-00001

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Abstract

Genome-wide scans have implicated several susceptibility loci, but linkage of 19p13 (IBD6) to Crohn's disease (CD) has not been fully replicated. We report a replication study of IBD6 in a UK Caucasian population. Two hundred eighty-four affected sibling pairs from 234 families were used for the linkage study. Linkage between IBD6 linkage and CD was replicated (LOD score = 1.59). Two candidate genes (DDXL and ICAM-1) within the IBD6 locus were examined in a case/control study with a total of 228 CD and 243 ulcerative colitis (UC) patients and 407 healthy controls. No association to either UC or CD was found in three novel intronic single nucleotide polymorphisms (SNPs) in DDXL. For ICAM-1, a significant association was found between K469 homozygosity and CD overall (39.9% vs 29.4%; Pc = 0.0096) and between E469 and fistulating disease (21.8% vs 10.0%, Pc = 0.030). In the UC group, limited disease extent was associated with homozygosity of the G241 allele (82.7% vs 64.7%, Pc = 0.0040). These data support linkage for CD at 19p13 and suggest that the amino acid polymorphisms in ICAM-1 may be associated with IBD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	affected sibling pair; Crohn's disease; genome-wide scanning; genetic markers; genotype; indeterminate colitis; inflammatory bowel disease; linkage analyses; maximum LOD score; non-parametric LOD score; susceptibility gene; ulcerative colitis
Publisher:	John Wiley & Sons
ISSN:	1078-0998
Last Modified:	12 Jun 2019 02:17
URI:	https://orca.cardiff.ac.uk/id/eprint/60802

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