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Mechanisms of bacterial resistance to microbicides

Maillard, Jean Yves 2012. Mechanisms of bacterial resistance to microbicides. In: Fraise, Adam P., Maillard, Jean Yves and Sattar, Syed A. eds. Russell, Hugo & Ayliffe's: Principles and Practice of Disinfection, Preservation and Sterilization, 5th Edition, Blackwell Publishing, pp. 108-120. (10.1002/9781118425831.ch6a)

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Abstract

The use of microbicides and the number of applications for microbicidal products in a wide range of fields have increased substantially over the last few years. Unfortunately, information on the activity of such microbicidal products in practice or following conditions mimicking their field application is not always available. This has led to situations where bacteria less susceptible or more resistant to microbicides have sometime been recovered from cases of human infections. There is now a better understanding of the mechanisms conferring bacterial resistance to microbicides and it is clear that bacteria have evolved and have the capability to withstand and survive exposure to high concentration of certain types of microbicides common in the healthcare industry in particular. This chapter aims to review the incidence of bacterial resistance, the mechanisms conferring resistance and questions the methods available to measure such resistance in bacteria. Important issues such as the dissemination of resistance and cross-resistance to chemotherapeutic antibiotics are also discussed.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RS Pharmacy and materia medica
Publisher: Blackwell Publishing
ISBN: 9781444333251
Last Modified: 04 Jun 2017 06:29
URI: http://orca.cf.ac.uk/id/eprint/60815

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