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Therapeutic drug monitoring (TDM)

Routledge, Philip Alexander and Hutchings, Alun 2013. Therapeutic drug monitoring (TDM). In: Wild, David ed. The immunoassay handbook : Theory and Applications of Ligand Binding, ELISA and Related Techniques, Oxford: Elsevier, pp. 945-962. (10.1016/B978-0-08-097037-0.00076-2)

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This chapter provides a review of the use of immunoassay in therapeutic drug monitoring. The immunoassay technology commonly used in this field is described (radioimmunoassay, enzyme-multiplied immunoassay technique, cloned enzyme donor immunoassay, enzyme-linked immunosorbent assay, homogeneous fluorescence enhancement and quenching assays, fluorescence polarization and microparticle enzyme immunoassay. Measurement of free drug concentration is reviewed and there is a section on practical aspects and assay interferences. The drugs are then reviewed in individual sections with these subsections: clinical applications, mode of administration, pharmacological effects, pharmacokinetics, therapeutic range, potentially toxic concentration, side effects and type of sample. The drugs described are: acecainide (n-acetylprocainamide), digoxin, digitoxin, procainamide, quinidine, theophylline, amikacin, gentamicin, tobramycin, vancomycin, carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin (diphenylhydantoin), primidone, topiramate, valproic acid, zonisamide, ciclosporin (cyclosporin), methotrexate, mycophenolic acid, sirolimus, tacrolimus, acetaminophen (paracetamol), and the tricyclic antidepressants amitriptyline, imipramine and desipramine.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RS Pharmacy and materia medica
Publisher: Elsevier
ISBN: 9780080970370
Last Modified: 05 Nov 2019 04:11

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