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Alginate-antacid combinations: raft formation and gastric retention studies

Hampson, Frank C., Jolliffe, Ian G., Bakhtyari, Arash, Taylor, Glyn, Sykes, John, Johnstone, Lesley M. and Dettmar, Peter W. 2010. Alginate-antacid combinations: raft formation and gastric retention studies. Drug Development and Industrial Pharmacy 36 (5) , pp. 614-623. 10.3109/03639040903388290

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Abstract

Alginate-based gastroesophageal reflux disease treatments have been used extensively and fall into two main categories. Those containing alginate as the principle active agent and those containing alginate in combination with a significant amount of antacid. Method: The effectiveness of the raft formed by a new alginate/antacid suspension (Gaviscon Double Action Liquid, GDAL), in which calcium carbonate was the main antacid ingredient, was compared with those of existing alginate/antacid suspensions. Result: GDAL had similar raft strength and improved raft resilience than Gaviscon Liquid (GL), and both were significantly greater than five other products tested. Gastric retention of GDAL was similar to that of GL. Conclusion: the in vitro and in vivo performance is maintained in the new GDAL formulation even with higher antacid levels and the product is as good as, or better than, previous formulations.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RS Pharmacy and materia medica
Uncontrolled Keywords: Alginate; antacid; formulation; gastric retention; gastroesophageal reflux; raft.
Publisher: Taylor & Francis
ISSN: 0363-9045
Last Modified: 04 Jun 2017 06:30
URI: http://orca.cf.ac.uk/id/eprint/61046

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