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In vitro secreted aspartyl proteinase activity of Candida albicans isolated from oral diseases and healthy oral cavities

Kuriyama, T., Williams, David Wynne and Lewis, Michael Alexander Oxenham 2003. In vitro secreted aspartyl proteinase activity of Candida albicans isolated from oral diseases and healthy oral cavities. Oral Microbiology and Immunology 18 (6) , pp. 405-407. 10.1046/j.0902-0055.2002.00100.x

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Abstract

The in vitro secreted aspartyl proteinase (SAP) activity of Candida albicans isolated from a variety of oral conditions, including healthy oral cavities, was determined. SAP activity (units/106cells/ml, ±SD) was 0.28 ± 0.33 for pseudomembranous candidosis isolates (n = 18), 0.35 ± 0.46 for chronic erythematous candidosis isolates (n = 21) and 0.30 ± 0.32 for chronic hyperplastic candidosis isolates (n = 50). SAP activity of 0.19 ± 0.22 was recorded for isolates from squamous cell carcinoma (n = 18), 0.26 ± 0.37 for burning mouth syndrome isolates (n = 29), 0.25 ± 0.38 for isolates from xerostomia (n = 15) and 0.39 ± 0.50 for isolates from lichen planus (n = 13). The SAP activity of isolates from oral disease states was significantly (P < 0.05) higher than that recorded for 28 isolates from healthy mouths (activity of 0.04 ± 0.03). However, there was no significant difference in the SAP activity between the three forms of clinical oral candidosis (P > 0.05). SAP activity was inhibited in control samples containing the SAP inhibitor, pepstatin A. These results indicate that C. albicans strains associated with oral disease have inherently higher SAP activity.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Subjects: R Medicine > RK Dentistry
Uncontrolled Keywords: Candida albicans; secreted aspartyl proteinase; oral candidosis.
Publisher: Wiley-Blackwell
ISSN: 0902-0055
Last Modified: 16 Apr 2019 20:29
URI: http://orca.cf.ac.uk/id/eprint/61067

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