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Characterisation of the inflammatory cell infiltrate in chronic hyperplastic candidosis of the oral mucosa

Williams, David Wynne, Potts, Albert John Cornel, Wilson, Melanie, Matthews, John B. and Lewis, Michael Alexander Oxenham 1997. Characterisation of the inflammatory cell infiltrate in chronic hyperplastic candidosis of the oral mucosa. Journal of Oral Pathology & Medicine 26 (2) , pp. 83-89. 10.1111/j.1600-0714.1997.tb00026.x

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Abstract

using immunocytochemical techniques. Nine specimens were stained for human kappa and lambda immunoglobulin light chains, CD68 antigen (macrophages), lysozyme (macrophages, granulocytes), CD3 antigen (T-lymphocytes), CD20 antigen (B-lymphocytes) and leucocyte common antigen (LCA). In addition, these and a further 13 specimens were also examined for immunoglobulin (Ig)-containing cells (IgA, IgG and IgM). The density of the infiltrate varied considerably between cases; T-lymphocytes were the dominant cell type (53.9%), with fewer B-lymphocytes (8.2%) and macrophages (14.2%). Many Ig-containing cells were seen, and although IgG-containing cells predominated, (60.8%, SD +/- 9.0) there was a high proportion of IgA-containing cells (36.7%, SD +/- 9.1) with few IgM-containing cells (2.5%, SD +/- 3.0). Many neutrophils, together with smaller numbers of T-lymphocytes and macrophages, were seen in the epithelium. It is suggested that mucosal defence to Candida infection involves a cell-mediated reaction in which there is recruitment of macrophages and local production of immunoglobulin with a prominent IgA component.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Subjects: R Medicine > RK Dentistry
Publisher: John Wiley & Sons
ISSN: 0904-2512
Last Modified: 16 Apr 2019 20:29
URI: http://orca.cf.ac.uk/id/eprint/61075

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