Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Tombola, a tesmin/TSO1 family protein, regulates transcriptional activation in the Drosophila male germline and physically interacts with Always early

Jiang, Jianqiao, Benson, E., Bausek, N., Doggett, K. and White-Cooper, Helen 2007. Tombola, a tesmin/TSO1 family protein, regulates transcriptional activation in the Drosophila male germline and physically interacts with Always early. Development 134 , pp. 1549-1559. 10.1242/dev.000521

Full text not available from this repository.

Abstract

During male gametogenesis a developmentally regulated and cell type specific transcriptional programme is activated in primary spermatocytes to prepare for differentiation of sperm. The Drosophila aly-class meiotic arrest loci (aly, comr, achi/vis and topi) are essential for activation of transcription of many differentiation-specific genes, and several genes important for meiotic cell cycle progression, thus linking meiotic divisions to cellular differentiation during spermatogenesis. Protein interaction studies suggests that the aly-class gene products form a chromatin-associated complex in primary spermatocytes. We identify, clone and characterise a new aly-class meiotic arrest gene, tombola (tomb), which encodes a testis-specific CXC domain protein that interacts with Aly. The tomb mutant phenotype is more like aly and comr than like achi/vis or topi in terms of target gene profile and chromosome morphology. tomb encodes a chromatin-associated protein required for localisation of Aly and Comr, but not Topi, to chromatin Reciprocally, aly and comr, but not topi or achi/vis, are required to maintain the normal localisation of Tomb. tomb and aly may be components of a complex paralogous to the Drosophila dREAM/MybMuv-B and C. elegans DRM transcriptional regulatory complexes.

Item Type: Article
Status: Published
Schools: Biosciences
Publisher: Company of Biologists
ISSN: 0950-1991
Last Modified: 04 Jun 2017 06:30
URI: http://orca.cf.ac.uk/id/eprint/61160

Citation Data

Cited 41 times in Scopus. View in Scopus. Powered By Scopus® Data

Cited 33 times in Web of Science. View in Web of Science.

Actions (repository staff only)

Edit Item Edit Item