Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

MBD2 deficiency does not accelerate p53 mediated lymphomagenesis

Sansom, Owen J., Bishop, Stefan Mark, Bird, Adrian and Clarke, Alan Richard 2005. MBD2 deficiency does not accelerate p53 mediated lymphomagenesis. Oncogene 24 (14) , pp. 2430-2432. 10.1038/sj.onc.1208166

Full text not available from this repository.


Recent studies using hypomorphic DNA methyltransferase 1 (DNMT1) alleles have suggested that strategies aiming to reduce DNA methylation may increase genomic instability and lymphomagenesis. Given our recent finding that loss of methyl-binding domain protein 2 (Mbd2) suppresses intestinal tumorigenesis, we have tested whether loss of Mbd2 increases lymphomagenesis by intercrossing Mbd2 deficient mice with p53 deficient and p53 heterozygous mice. Unlike DNMT1, loss of Mbd2 does not accelerate lymphomagenesis, arguing that MBD2 may represent a better potential therapeutic target than DNMT1.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: MBD2; p53; DNA methylation; tumorigenesis; chemoprevention; genomic instability.
Publisher: Nature Publishing
ISSN: 0950-9232
Last Modified: 18 Jan 2018 21:06

Citation Data

Cited 10 times in Google Scholar. View in Google Scholar

Cited 7 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item