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Wnt-Cadherin connections in normal and neoplastic mammary epithelium

Meniel, Valerie and Clarke, Alan Richard 2003. Wnt-Cadherin connections in normal and neoplastic mammary epithelium. Journal of Mammary Gland Biology and Neoplasia 8 (4) , pp. 435-447. 10.1023/B:JOMG.0000017430.12210.37

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Since the early recognition that the murine Wnt locus is frequently activated by insertion of the mouse mammary tumour virus, the Wnt pathway has become increasingly associated with both normal and abnormal mammary gland development. This link is further underlined by an emerging role for Wnt deregulation in human mammary neoplasia. The control of transcription through the Wnt signaling pathway is clearly a prime element of this role; however, components of the Wnt pathway possess many functions in addition to their signaling activity, interacting with multiple factors implicated in cellular control processes. Prominent amongst these are the cadherins, which have characterized roles in mediating cell–cell adhesion, and which have been independently implicated in mammary neoplasia. The close interplay between these 2 systems will be discussed in this review with reference both to the normal development of the mammary gland and to the onset of neoplasia in this tissue.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
European Cancer Stem Cell Research Institute (ECSCRI)
Subjects: Q Science > Q Science (General)
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords: E-cadherin; β-catenin; transcriptional repression; methylation; phosphorylation; protein interactions; mammary tumor.
Publisher: Springer
ISSN: 1083-3021
Last Modified: 04 Jun 2017 06:31

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