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Neurogenic potential of progenitor cells isolated from postmortem human Parkinsonian brains

Wang, Shanshan, Okun, Michael S., Suslov, Oleg, Zheng, Tong, McFarland, Nikolaus R., Vedam-Mai, Vinata, Foote, Kelly D., Roper, Steven N., Yachnis, Anthony T., Siebzehnrubl, Florian and Steindlera, Dennis A. 2012. Neurogenic potential of progenitor cells isolated from postmortem human Parkinsonian brains. Brain Research 1464 , pp. 61-72. 10.1016/j.brainres.2012.04.039

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Abstract

The success of cellular therapies for Parkinson's disease (PD) will depend not only on a conducive growth environment in vivo, but also on the ex vivo amplification and targeted neural differentiation of stem/progenitor cells. Here, we demonstrate the in vitroproliferative and differentiation potential of stem/progenitor cells, adult human neural progenitor cells (“AHNPs”) isolated from idiopathic PD postmortem tissue samples and, to a lesser extent, discarded deep brain stimulation electrodes. We demonstrate that these AHNPs can be isolated from numerous structures (e.g.substantia nigra, “SN”) and are able to differentiate into both glia and neurons, but only under particular growth conditions including co-culturing with embryonic stem cell-derived neural precursors (“ESNPs”); this suggests that PD multipotent neural stem/progenitor cells do reside within the SN and other areas, but by themselves appear to lack key factors required for neuronal differentiation. AHNPs engraft following ex vivoexpansion and transplantation into the rodent brain, demonstrating their regenerative potential. Our data demonstrate the presence and capacity of endogenous stem/progenitor cells in the PD brain.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
European Cancer Stem Cell Research Institute (ECSCRI)
ISSN: 0006-8993
Last Modified: 04 Jun 2017 06:31
URI: http://orca.cf.ac.uk/id/eprint/61392

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