Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

PPARδ status and mismatch repair mediated neoplasia in the mouse intestine

Reed, Karen Ruth, Sansom, Owen J., Hayes, Anthony Joseph, Gescher, Andreas J., Peters, Jefferey M. and Clarke, Alan Richard 2006. PPARδ status and mismatch repair mediated neoplasia in the mouse intestine. BMC Cancer 6 (113) 10.1186/1471-2407-6-113

[img]
Preview
PDF - Published Version
Available under License Creative Commons Attribution.

Download (254kB) | Preview

Abstract

Therapeutic regulation of PPARδ activity using selective agonists has been proposed for various disorders. However, the consequences of altered peroxisome proliferator-activated receptor delta (PPARδ) activity in the context of intestinal tumourigenesis remain somewhat unclear. Contradictory evidence suggesting PPARδ either attenuates or potentiates intestinal neoplasia. To further investigate the PPARδ dependency of intestinal tumourigenesis, we have analysed the consequences of PPARδ deficiency upon intestinal neoplasia occurring in mice with impaired mismatch DNA repair.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
European Cancer Stem Cell Research Institute (ECSCRI)
Subjects: Q Science > Q Science (General)
Q Science > QL Zoology
Additional Information: PDF uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/1471-2407/ [accessed 16/10/14]
Publisher: BioMed Central
ISSN: 1471-2407
Date of First Compliant Deposit: 30 March 2016
Last Modified: 18 Jan 2018 21:09
URI: http://orca.cf.ac.uk/id/eprint/61419

Citation Data

Cited 7 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics