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Clinical relevance of cancer genome sequencing

Ku, Chee Seng, Cooper, David Neil and Roukos, D. H. 2013. Clinical relevance of cancer genome sequencing. World Journal of Gastroenterology 19 (13) , pp. 2011-2018. 10.3748/wjg.v19.i13.2011

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Abstract

The arrival of both high-throughput and bench-top next-generation sequencing technologies and sequence enrichment methods has revolutionized our approach to dissecting the genetic basis of cancer. These technologies have been almost invariably employed in whole-genome sequencing (WGS) and whole-exome sequencing (WES) studies. Both WGS and WES approaches have been widely applied to interrogate the somatic mutational landscape of sporadic cancers and identify novel germline mutations underlying familial cancer syndromes. The clinical implications of cancer genome sequencing have become increasingly clear, for example in diagnostics. In this editorial, we present these advances in the context of research discovery and discuss both the clinical relevance of cancer genome sequencing and the challenges associated with the adoption of these genomic technologies in a clinical setting.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords: Next-generation sequencing, Exome, Cancer, Diagnostics, Familial cancer syndrome, Somatic mutation
Additional Information: Pdf uploaded in accordance with publisher's policy at http://www.wjgnet.com/bpg/subscribe.htm (accessed 22/07/2014).
Publisher: Baishideng Publishing Group
ISSN: 1007-9327
Date of First Compliant Deposit: 30 March 2016
Last Modified: 04 Jun 2017 06:31
URI: http://orca.cf.ac.uk/id/eprint/61481

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