"Classic NMR": an in-situ NMR strategy for mapping the time-evolution of crystallization processes by combined liquid-state and solid-state measurements

Hughes, Colan E., Williams, P. Andrew and Harris, Kenneth D. M. ORCID: https://orcid.org/0000-0001-7855-8598 2014. "Classic NMR": an in-situ NMR strategy for mapping the time-evolution of crystallization processes by combined liquid-state and solid-state measurements. Angewandte Chemie International Edition 53 (34) , pp. 8939-8943. 10.1002/anie.201404266

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Abstract

A new in-situ NMR strategy (termed CLASSIC NMR) for mapping the evolution of crystallization processes is reported, involving simultaneous measurement of both liquid-state and solid-state NMR spectra as a function of time. This combined strategy allows complementary information to be obtained on the evolution of both the solid and liquid phases during the crystallization process. In particular, as crystallization proceeds (monitored by solid-state NMR), the solution state becomes more dilute, leading to changes in solution-state speciation and the modes of molecular aggregation in solution, which are monitored by liquid-state NMR. The CLASSIC NMR experiment is applied here to yield new insights into the crystallization of m-aminobenzoic acid.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Subjects:	Q Science > QD Chemistry
Uncontrolled Keywords:	Crystal growth; in-situ studies; solid-state nmr spectroscopy; time-dependent processes.
Publisher:	Wiley
ISSN:	1433-7851
Funders:	EPSRC, BBSRC
Date of First Compliant Deposit:	30 March 2016
Last Modified:	08 May 2023 13:02
URI:	https://orca.cardiff.ac.uk/id/eprint/61648

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