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A randomised, double blind, crossover study of the effects of CLA isomers on inflammation, body composition, metabolic profiles and vascular function in subjects with the metabolic syndrome

Bolusani, Hemanth 2013. A randomised, double blind, crossover study of the effects of CLA isomers on inflammation, body composition, metabolic profiles and vascular function in subjects with the metabolic syndrome. MD Thesis, Cardiff University.
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Abstract

A variety of individual and population based approaches to prevention and management of obesity are required and there is an increasing interest in functional foods and natriceuticals. Conjugated linoleic acid (CLA) has generated enormous interest in this context due to their ability to modulate PPAR’s and the associated metabolic processes. ! AIMS & METHODS ! This study aimed to investigate the effects of CLA supplementation in a randomised, double blind crossover trial on inflammation, vascular function and metabolic profiles in subjects with the metabolic syndrome. !! RESULTS ! This study utilised a cross-over design to investigate any differences in outcomes using 9,11 CLA isomer in comparison to the CLA mixture. The results revealed no significant differences at baseline between the two groups and a relatively small number of significant outcomes (peripheral SBP, aPWV, HDL-cholesterol, adiponectin, platelet aggregation and HOMA B). As there was a lack of substantial differences in the two treatments and an inconsistency in specifying these differences to a specific isomer, further analysis was undertaken combining the data from both groups and comparing the outcomes at baseline and at the end of the treatment using a paired‘t’ test. Results from this sub analysis showed a significant increase in circulating sRAGE levels (‘p’=0.002) along with reductions in aortic PWV (‘p’=0.003) and markers of endothelial and platelet function. There were no changes in body composition or insulin sensitivity although adiponectin levels were elevated (‘p’=0.003) and resistin levels decreased markedly (‘p’<0.005) following the treatment. !! CONCLUSIONS ! Dietary supplementation with CLA seems to produce a number of vascular benefits which are noted to be independent of its metabolic effects and mediated possibly by attenuating inflammation through changes in circulatory sRAGE. This is of considerable clinical relevance and may open new perspectives and offer effective strategies to reduce the CVD burden in the metabolic syndrome. !

Item Type: Thesis (MD)
Status: Unpublished
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Date of First Compliant Deposit: 30 March 2016
Last Modified: 19 Mar 2016 23:42
URI: http://orca.cf.ac.uk/id/eprint/61649

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