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Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta

Smalley, Matthew John, Signoret, Nathalie, Robertson, David, Tilley, Alan, Hann, Anthony, Ewan, Kenneth, Ding, Yanning, Paterson, Hugh and Dale, Trevor Clive 2005. Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta. Journal of Cell Science 118 (22) , pp. 5279-5289. 10.1242/jcs.02647

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Abstract

Dishevelled family proteins are multidomain intracellular transducers of Wnt signals. Ectopically expressed mammalian Dishevelled 2 (Dvl-2) activates downstream signalling and localises to cytoplasmic puncta. It has been suggested that these Dvl-2-containing structures correspond to intracellular vesicles and may be involved in the Wnt signal transduction process. We report that cytoplasmic puncta are primarily formed in cells expressing Dvl-2 at high levels. Lower levels of expression can activate signalling without forming puncta. The structures do not localise with markers of the early or late endocytic pathway and time-lapse analysis demonstrates that Dvl-2 puncta move in a random fashion over short distances but do not originate from the plasma membrane. Based on our findings, we propose that Dvl-2 puncta are protein aggregates that are not required for signalling.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: The Company of Biologists Ltd
ISSN: 0021-9533
Funders: Cancer Research UK
Last Modified: 24 Apr 2019 12:22
URI: http://orca.cf.ac.uk/id/eprint/61743

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