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Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART)

Burr, Michael Leslie, Fehily, A. M., Gilbert, J. F., Rogers, S., Holliday, R. M., Sweetnam, P. M., Elwood, Peter Crighton and Deadman, N. M. 1989. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). The Lancet 30 (2) , pp. 757-761. 10.1016/s0140-6736(89)90828-3

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A randomised controlled trial with a factorial design was done to examine the effects of dietary intervention in the secondary prevention of myocardial infarction (MI). 2033 men who had recovered from MI were allocated to receive or not to receive advice on each of three dietary factors: a reduction in fat intake and an increase in the ratio of polyunsaturated to saturated fat, an increase in fatty fish intake, and an increase in cereal fibre intake. The advice on fat was not associated with any difference in mortality, perhaps because it produced only a small reduction (3-4%) in serum cholesterol. The subjects advised to eat fatty fish had a 29% reduction in 2 year all-cause mortality compared with those not so advised. This effect, which was significant, was not altered by adjusting for ten potential confounding factors. Subjects given fibre advice had a slightly higher mortality than other subjects (not significant). The 2 year incidence of reinfarction plus death from ischaemic heart disease was not significantly affected by any of the dietary regimens. A modest intake of fatty fish (two or three portions per week) may reduce mortality in men who have recovered from MI.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Additional Information: Publication Types Clinical Trial Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't Full Text Sources Elsevier Science Gale Databases Medical Dietary Fats - MedlinePlus Health Information Dietary Fiber - MedlinePlus Health Information Heart Attack - MedlinePlus Health Information Molecular Biology Databases CHOLESTEROL - HSDB
Publisher: Elsevier
ISSN: 0140-6736
Last Modified: 04 Jun 2017 06:33

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