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Coffee, blood pressure and plasma lipids: a randomized controlled trial

Burr, Michael Leslie, Gallacher, John Edward, Butland, B. K., Bolton, C. H. and Downs, L. G. 1989. Coffee, blood pressure and plasma lipids: a randomized controlled trial. European Journal of Clinical Nutrition 43 (7) , pp. 477-483.

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Abstract

A randomized controlled trial was conducted to examine the effects of coffee (as commonly drunk in Britain) on blood pressure and plasma lipids in healthy subjects. Fifty-four subjects followed three regimens successively, the order being randomized according to a Latin square design: five or more cups of coffee daily for 4 weeks; five or more cups of decaffeinated coffee daily for 4 weeks but no ordinary coffee; no coffee for 4 weeks. Coffee appeared to cause a small rise (of 3 mm Hg) in recumbent systolic blood pressure; this effect was less than, and obscured by, changes induced by posture and mild stress. No consistent changes attributable to coffee were found in diastolic blood pressure or pulse rate. Small changes in the expected directions occurred in plasma high density lipoprotein (HDL) cholesterol and apolipoprotein AI (decrease), and in total cholesterol, non-HDL cholesterol and apolipoprotein B (increase), but none of these were statistically significant. The effect of coffee on risk of heart disease in Britain is probably small.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Uncontrolled Keywords: Adolescent,Adult,BloodPressure/drugeffects*,Caffeine/pharmacology,Coffee*,Female,Heart Rate/drug effects,Humans,Lipids/blood*,Male,Middle Aged Substances Coffee Lipids Caffeine
Additional Information: Publication Types Clinical Trial Randomized Controlled Trial Other Literature Sources COS Scholar Universe Molecular Biology Databases CAFFEINE - HSDB
Publisher: Nature Publishing Group
ISSN: 0954-3007
Last Modified: 25 Oct 2016 03:40
URI: http://orca.cf.ac.uk/id/eprint/61892

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