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Regional localization and characterization of a DNA segment on the long arm of chromosome 21

Cooper, David Neil, Niemann, S. C., Gosden, J. R., Mitchell, A. R., Goate, A. M., Rajendran, G. S., Miller, D. A., Lim, L. and Schmidtke, J. 1987. Regional localization and characterization of a DNA segment on the long arm of chromosome 21. Human Genetics 75 (2) , pp. 129-135. 10.1007/BF00591073

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Abstract

A human genomic DNA fragment, pAM37 (HGM8; D21S22), was mapped to chromosome 21q2.1-q2.21 by in situ hybridization. This segment is therefore situated on the boundary of the “pathological region” of Down syndrome. A genomic restriction map encompassing 35 kb of chromosome 21 was derived and two restriction fragment length polymorphisms (RFLPs) were mapped and characterized. A homologous sequence was detected in the mouse genome but no homologous RNA was detected in a range of human tissues. This DNA segment will contribute to the linkage mapping of chromosome 21 and will facilitate delineation of the pathological region of Down syndrome.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: Q Science > QH Natural history > QH426 Genetics
Publisher: Springer
ISSN: 0340-6717
Last Modified: 04 Jun 2017 06:33
URI: http://orca.cf.ac.uk/id/eprint/62068

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