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DNA methylation and CpG suppression

Cooper, David Neil and Gerber-Huber, Susan 1985. DNA methylation and CpG suppression. Cell Differentiation 17 (3) , pp. 199-205. 10.1016/0045-6039(85)90488-9

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Abstract

Cytosine methylation in vertebrate genomes occurs predominantly at the dinucleotide CpG. This dinucleotide is deficient in vertebrate DNA, an observation which has hitherto been explained by passive deamination of S-methylcytosine to thymidine. Since the frequency and distribution of CpG may prove to be a useful indirect means to study the function of DNA methylation, it is of interest that the observed ‘CpG suppression’ is less apparent within and around coding sequences. A variety of different mechanisms now appear to be responsible for maintaining a relatively high CpG level in these regions despite the apparent attendant disadvantage of mutation.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
ISSN: 0045-6039
Last Modified: 04 Jun 2017 06:33
URI: http://orca.cf.ac.uk/id/eprint/62082

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