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Evidence that a DISC1 frame-shift deletion associated with psychosis in a single family may not be a pathogenic mutation

Green, E. K., Norton, N., Peirce, T., Grozeva, D., Kirov, George, Owen, Michael John, O'Donovan, Michael Conlon and Craddock, Nicholas John 2006. Evidence that a DISC1 frame-shift deletion associated with psychosis in a single family may not be a pathogenic mutation. Molecular Psychiatry 11 (9) , pp. 798-799. 10.1038/sj.mp.4001853

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Abstract

Recently, Sachs et al.1 reported intra-familial association of a frame-shift mutation at the extreme 3' end of exon 12 of the gene Disrupted in Schizophrenia 1 (DISC1) with schizophrenia and schizoaffective phenotypes. In our own sample, we identified this mutation in none of 655 schizophrenia cases but two of 694 non-psychiatrically screened controls. Our findings suggest that this mutation may not play a major role in influencing susceptibility to psychosis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: Nature Publishing Group
ISSN: 1359-4184
Last Modified: 17 May 2019 21:26
URI: http://orca.cf.ac.uk/id/eprint/62135

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