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Genetics of affective (mood) disorders

Craddock, Nicholas John and Forty, Elizabeth 2006. Genetics of affective (mood) disorders. European Journal of Human Genetics 14 (6) , pp. 660-668. 10.1038/sj.ejhg.5201549

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The enormous public health importance of mood disorders, when considered alongside their substantial heritabilities, has stimulated much work, predominantly in bipolar disorder but increasingly in unipolar depression, aimed at identifying susceptibility genes using both positional and functional molecular genetic approaches. Several regions of interest have emerged in linkage studies and, recently, evidence implicating specific genes has been reported; the best supported include BDNF and DAOA but further replications are required and phenotypic relationships and biological mechanisms need investigation. The complexity of psychiatric phenotypes is demonstrated by (a) the evidence accumulating for an overlap in genetic susceptibility across the traditional classification systems that divide disorders into schizophrenia and mood disorders, and (b) evidence suggestive of gene-environment interactions.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Publisher: Nature Publishing Group
ISSN: 1018-4813
Date of Acceptance: 10 November 2005
Last Modified: 12 Sep 2017 11:27

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