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Vitamin D receptor variants in 192 patients with schizophrenia and other psychiatric diseases

Yan, Jin, Feng, Jinong, Craddock, Nicholas John, Jones, Ian Richard, Cook, Edwin H., Goldman, David, Heston, Leonard L., Chen, Jiesheng, Burkhart, Patricia, Li, Wenyan, Shibayama, Akane and Sommer, Steve S. 2005. Vitamin D receptor variants in 192 patients with schizophrenia and other psychiatric diseases. Neuroscience Letters 380 (1-2) , pp. 37-41. 10.1016/j.neulet.2005.01.018

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Intriguing parallels have been noted previously between the biology of Vitamin D and the epidemiology of schizophrenia. We have scanned the Vitamin D receptor (VDR) gene by DOVAM-S (Detection of Virtually All Mutations-SSCP), a robotically enhanced multiplexed scanning method. In total, 100 patients with schizophrenia (86 Caucasians and 14 African-Americans) were scanned. In addition, pilot experiments were performed in patients with bipolar disorder (BPD) (24), autism (24), attention deficit hyperactivity disorder (ADHD) (24), and alcoholism (20). A total of 762 kb of the VDR genomic sequence was scanned. R208N and V339I were each found in one African-American patient, while absent in 35 African-American controls without schizophrenia (2/14 versus 0/35, P = 0.08). Within the power of the study (≥1.6-fold relative risk), the common M1T variant is not associated with schizophrenia. In the 92 scanned patients with other psychiatric diseases, R173S was found in a single patient with bipolar disorder. In conclusion, we describe three novel structural variants of the Vitamin D receptor. Further study is required to clarify their role, if any, in psychiatric disease.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher: Elsevier
ISSN: 0304-3940
Last Modified: 04 Jun 2017 06:34

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