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Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases

Feng, Jinong, Chen, Jiesheng, Yan, Jin, Jones, Ian Richard, Craddock, Nicholas John, Cook, Edwin H., Goldman, David, Heston, Leonard L. and Sommer, Steve S. 2005. Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 133B (1) , pp. 50-53. 10.1002/ajmg.b.30113

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Abstract

Retinoid receptors (RARs and RXRs) regulate brain morphogenesis and function. Defects in these receptors may contribute to schizophrenia or other psychiatric diseases. To test the hypothesis that genetic variants of the retinoid receptor genes may predispose to schizophrenia and other psychiatric diseases, the six RAR and RXR genes and a heterodimer partner, the NURR1 gene, were scanned in 100 schizophrenia patients, along with pilot studies in 20–24 patients with bipolar disorder (BPD), attention-deficit hyperactivity disorder (ADHD), autism, or alcoholism. A total of 5.4 megabases of genomic sequence was scanned. No variants affecting protein structure or expression (VAPSEs) were found in four of the genes. One uncommon missense variant was found in each of the RARβ, RARγ, and RXRγ genes. We conclude that structural variants in the RAR/RXR and NURR1 genes do not play a major role in the etiology of schizophrenia.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Publisher: Wiley-Blackwell
ISSN: 1552-4841
Last Modified: 04 Jun 2017 06:34
URI: http://orca.cf.ac.uk/id/eprint/62158

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