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Obtaining new composite biomaterials by means of mineralization of methacrylate hydrogels using the reaction-diffusion method

Ramadan, Yousof, González-Sánchez, M. Isabel, Hawkins, Karl, Rubio-Retama, Jorge, Valero, Edelmira, Perni, Stefano, Prokopovich, Polina and López-Cabarcos, Enrique 2014. Obtaining new composite biomaterials by means of mineralization of methacrylate hydrogels using the reaction-diffusion method. Materials Science and Engineering C 42 , pp. 696-704. 10.1016/j.msec.2014.06.017

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The present paper describes the synthesis and characterization of a new polymeric biomaterial mineralized with calcium phosphate using the reaction–diffusion method. The scaffold of this biomaterial was a hydrogel constituted by biocompatible polyethylene glycol methyl ether methacrylate (PEGMEM) and 2-(dimethylamino)ethyl methacrylate (DMAEM), which were cross-linked with N-N’-methylenebisacrylamide (BIS). The cross-linking content of the hydrogels was varied from 0.25% to 15% (w/w). The gels were used as matrix where two reactants (Na2HPO4 and CaCl2) diffused from both ends of the gel and upon encountering produced calcium phosphate crystals that precipitated within the polymer matrix forming bands. The shape of the crystals was tuned by modifying the matrix porosity in such a way that when the polymer matrix was slightly reticulated the diffusion reaction produced round calcium phosphate microcrystals, whilst when the polymer matrix was highly reticulated the reaction yielded flat calcium phosphate crystals. Selected area electron diffraction performed on the nanocrystals that constitute the microcrystals showed that they were formed by Brushite (CaHPO4.2H2O). This new composite material could be useful in medical and dentistry applications such as bone regeneration, bone repair or tissue engineering.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Engineering
Publisher: Elsevier
ISSN: 0928-4931
Date of First Compliant Deposit: 30 March 2016
Last Modified: 21 Feb 2019 11:47

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Cited 3 times in Google Scholar. View in Google Scholar

Cited 4 times in Scopus. View in Scopus. Powered By Scopus® Data

Cited 1 time in Web of Science. View in Web of Science.

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