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Differentiation of mouse embryonic stem cells into a defined neuronal lineage

Bibel, Miriam, Richter, Jens, Schrenk, Katrin, Tucker, Kerry Lee, Staiger, Volker, Korte, Martin, Goetz, Magdalena and Barde, Yves-Alain 2004. Differentiation of mouse embryonic stem cells into a defined neuronal lineage. Nature Neuroscience 7 (9) , pp. 1003-1009. 10.1038/nn1301

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Although it has long been known that cultured embryonic stem cells can generate neurons, the lineage relationships with their immediate precursors remain unclear. We report here that selection of highly proliferative stem cells followed by treatment with retinoic acid generated essentially pure precursors that markers identified as Pax-6-positive radial glial cells. As they do in vivo, these cells went on to generate neurons with remarkably uniform biochemical and electrophysiological characteristics.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
ISSN: 1097-6256
Last Modified: 04 Jun 2017 06:34

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