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Strain-specific complementation between NRIF1 and NRIF2, two zinc finger proteins sharing structural and biochemical properties

Benzel, Isabel, Barde, Yves-Alain and Casademunt, Elisabeth 2001. Strain-specific complementation between NRIF1 and NRIF2, two zinc finger proteins sharing structural and biochemical properties. Gene 281 (1-2) , pp. 19-30. 10.1016/S0378-1119(01)00730-2

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Abstract

The zinc finger protein NRIF (neurotrophin receptor interacting factor) was originally identified by virtue of its interaction with the neurotrophin receptor p75NTR and its participation in embryonic apoptosis. Targeted deletion of the nrif gene in mice is embryonically lethal in the C57BL6 genetic background, where it blocks cell cycle progression, but not in the Sv129 strain. We have now identified a second, highly homologous nrif gene, designated nrif2, encoding a protein with similar structural and biochemical properties as well as subcellular distribution as NRIF1, and whose over-expression in transfected fibroblasts also correlates with impaired BrdU incorporation. Unexpectedly, the nrif2 transcript becomes significantly upregulated in nrif1−/− mice only in Sv129, the genetic background where the mutants are viable, suggesting that the functional complementation of the two nrif genes may be strain-specific.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QH Natural history > QH426 Genetics
Q Science > QP Physiology
Uncontrolled Keywords: KRAB domain; SCAN domain; Embryonic lethality; Genetic background; Cell cycle arrest
Publisher: Elsevier
ISSN: 0378-1119
Last Modified: 04 Jun 2017 06:34
URI: http://orca.cf.ac.uk/id/eprint/62304

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