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Comprehensive strategies to study neuronal function in transgenic animal models

Carter, David Allan 2004. Comprehensive strategies to study neuronal function in transgenic animal models. Biological psychiatry 55 (8) , pp. 785-788. 10.1016/j.biopsych.2003.07.005

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Abstract

In the last 20 years of transgenic research, transgenic technology has been developed and refined to provide a seemingly comprehensive range of experimental approaches to questions of neuronal gene function; however, parallel developments in other technologies, such as whole genome sequencing and microarray analysis of gene expression, has meant that the questions have gotten harder. The complexity of neuronal systems and the difficulty of modeling neurologic diseases in rodents also present considerable challenges to molecular neuroscientists. Future functional genomic studies of brain and behavior will involve the full range of available transgenic methods and the incorporation of new technologies, including RNA interference.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QH Natural history > QH426 Genetics
Q Science > QP Physiology
Uncontrolled Keywords: Transgenic; RNAi; knockout; mouse; rat
Publisher: Elsevier
ISSN: 0006-3223
Last Modified: 04 Jun 2017 06:34
URI: http://orca.cf.ac.uk/id/eprint/62329

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