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The properties of reticular thalamic neuron GABAA IPSCs of absence epilepsy rats lead to enhanced network excitability

Tóth, Tibor Istvan, Bessaïh, T., Leresche, Nathalie and Crunelli, Vincenzo 2007. The properties of reticular thalamic neuron GABAA IPSCs of absence epilepsy rats lead to enhanced network excitability. European Journal of Neuroscience 26 (7) , pp. 1832-1844. 10.1111/j.1460-9568.2007.05800.x

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Abstract

Both human investigations and studies in animal models have suggested that abnormalities in GABAA receptor function have a potential role in the pathophysiology of absence seizures. Recently we showed that, prior to seizure onset, GABAA IPSCs in thalamic reticular (NRT) neurons of genetic absence epilepsy rats from Strasbourg (GAERS) had a 25% larger amplitude, a 40% faster decay and a 45% smaller paired-pulse depression than those of nonepileptic control (NEC) rats. By means of a novel mathematical description, the properties of both GAERS and NEC GABAergic synapses can be mimicked. These model synapses were then used in an NRT network model in order to investigate their potential impact on the neuronal firing patterns. Compared to NEC, GAERS NRT neurons show an overall increase in excitability and a higher frequency and regularity of firing in response to periodic input signals. Moreover, in response to randomly distributed stimuli, the GAERS but not the NEC model produces resonance between 7 and 9 Hz, the frequency range of spike–wave discharges in GAERS. The implications of these results for the epileptogenesis of absence seizures are discussed.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: Q Science > QH Natural history
Q Science > QP Physiology
Uncontrolled Keywords: GAERS; paired pulse depression; presynaptic inhibition; probabilistic network model; T-type calcium current
Publisher: Wiley
ISSN: 0953-816X
Last Modified: 10 Oct 2017 15:49
URI: http://orca.cf.ac.uk/id/eprint/62333

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