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Are corticothalamic ‘up’ states fragments of wakefulness?

Destexhe, Alain, Hughes, Stuart W., Rudolph, Michelle and Crunelli, Vincenzo 2007. Are corticothalamic ‘up’ states fragments of wakefulness? Trends in Neurosciences 30 (7) , pp. 334-342. 10.1016/j.tins.2007.04.006

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Abstract

The slow (<1 Hz) oscillation, with its alternating ‘up’ and ‘down’ states in individual neurons, is a defining feature of the electroencephalogram (EEG) during slow-wave sleep (SWS). Although this oscillation is well preserved across mammalian species, its physiological role is unclear. Electrophysiological and computational evidence from the cortex and thalamus now indicates that slow-oscillation ‘up’ states and the ‘activated’ state of wakefulness are remarkably similar dynamic entities. This is consistent with behavioural experiments suggesting that slow-oscillation ‘up’ states provide a context for the replay, and possible consolidation, of previous experience. In this scenario, the T-type Ca2+ channel-dependent bursts of action potentials that initiate each ‘up’ state in thalamocortical (TC) neurons might function as triggers for synaptic and cellular plasticity in corticothalamic networks. This review is part of the INMED/TINS special issue Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/TINS symposium (http://inmednet.com).

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Neuroscience and Mental Health Research Institute (NMHRI)
Publisher: Cell Press
ISSN: 0166-2236
Last Modified: 04 Jun 2017 06:34
URI: http://orca.cf.ac.uk/id/eprint/62335

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