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The corridor task: Striatal lesion effects and graft-mediated recovery in a model of Huntington's disease

Döbrössy, Máté D. and Dunnett, Stephen Bruce 2007. The corridor task: Striatal lesion effects and graft-mediated recovery in a model of Huntington's disease. Behavioural Brain Research 179 (2) , pp. 326-330. 10.1016/j.bbr.2007.02.030

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Abstract

Experimental validation of cell replacement therapy as a treatment of neurodegenerative diseases requires the demonstration of graft-mediated behavioural recovery. The Corridor task proved to be simple and efficient to conduct with a robust ipsilateral retrieval bias in our rodent Huntington's disease model. The Corridor task is a viable behavioural option, particularly to non-specialised laboratories, for the evaluation of lateralised striatal damage and the probing of alternative therapeutic strategies, including transplantation.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Elsevier
ISSN: 0166-4328
Last Modified: 04 Jun 2017 06:34
URI: http://orca.cf.ac.uk/id/eprint/62347

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