Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

The activity and inhibition of the food vacuole plasmepsin from the rodent malaria parasite Plasmodium chabaudi

Martins, Tiago M., Domingos, Ana, Berry, Colin and Wyatt, David 2006. The activity and inhibition of the food vacuole plasmepsin from the rodent malaria parasite Plasmodium chabaudi. Acta Tropica 97 (2) , pp. 212-218. 10.1016/j.actatropica.2005.11.001

Full text not available from this repository.

Abstract

The rodent malaria parasite Plasmodium chabaudi encodes one food vacuole plasmepsin—the aspartic proteinases important in haemoglobin degradation. A recombinant form of this enzyme was found to cleave a variety of peptide substrates and was susceptible to a selection of naturally occurring and synthetic inhibitors, displaying an inhibition profile distinct from that of aspartic proteinases from other malaria parasites. In addition, inhibitors of HIV proteinase that kill P. chabaudi in vivo were also inhibitors of this new plasmepsin. P. chabaudi is a widely used model for human malaria species and, therefore, the characterisation of this plasmepsin is an important contribution towards understanding its biology.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: Rodent malaria model; Plasmodium chabaudi; Aspartic proteinase; New plasmepsin.
Publisher: Elsevier
ISSN: 0001-706X
Last Modified: 04 Jun 2017 06:36
URI: http://orca.cf.ac.uk/id/eprint/62585

Citation Data

Cited 18 times in Google Scholar. View in Google Scholar

Cited 14 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item