Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

The temporal architecture of eukaryotic growth

Lloyd, David and Murray, Douglas B. 2006. The temporal architecture of eukaryotic growth. FEBS Letters 580 (12) , pp. 2830-2835. 10.1016/j.febslet.2006.02.066

Full text not available from this repository.

Abstract

Coherence of the time structure of growing organisms depends on a metronome-like orchestration. In a continuously perfused culture of Saccharomyces cerevisiae the redox state of the cell shows a temperature-compensated oscillation manifest in respiratory cycles, which are measured by continuous and non-invasive electrodes of probes such as dissolved oxygen and probes such as fluorometric NAD(P)H. Although the entire transcriptome exhibits low-amplitude oscillatory behaviour, transcripts involved in the vast majority of metabolism, stress response, cellular structure, protein turnover, mRNA turnover, and DNA synthesis are amongst the top oscillators and their orchestration occurs by an intricate network of transcriptional regulators. Therefore cellular auto-dynamism is a function of a large ensemble of excitable intracellular components of that self-organized temporally and spatially that encompasses mitochondrial, nuclear, transcriptional and metabolic dynamics, coupled by cellular redox state.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
Publisher: Elsevier
ISSN: 0014-5793
Last Modified: 04 Jun 2017 06:36
URI: http://orca.cf.ac.uk/id/eprint/62665

Citation Data

Cited 55 times in Google Scholar. View in Google Scholar

Cited 51 times in Scopus. View in Scopus. Powered By Scopus® Data

Cited 35 times in Web of Science. View in Web of Science.

Actions (repository staff only)

Edit Item Edit Item