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Ultradian metronome: timekeeper for orchestration of cellular coherence

Lloyd, David and Murray, Douglas B. 2005. Ultradian metronome: timekeeper for orchestration of cellular coherence. Trends in Biochemical Sciences 30 (7) , pp. 373-377. 10.1016/j.tibs.2005.05.005

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Abstract

Dynamic intracellular spatial and temporal organization emerges from spontaneous synchronization of a massive array of weakly coupled oscillators; the majority of subcellular processes are implicated in this integrated expression of cellular physiology. Evidence for this view comes mainly from studies of Saccharomyces cerevisiae growing in self-synchronized continuous cultures, in which a temperature-compensated ultradian clock (period of ∼40 min) couples fermentation with redox state in addition to the transcriptome and cell-division-cycle progression. Functions for ultradian clocks have also been determined in other yeasts (e.g. Schizosaccharomyces pombe and Candida utilis), seven protists (e.g. Acanthamoeba castellanii and Paramecium tetraurelia), as well as cultured mammalian cells. We suggest that ultradian timekeeping is a basic universal necessity for coordinated intracellular coherence.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Elsevier
ISSN: 0968-0004
Last Modified: 04 Jun 2017 06:36
URI: http://orca.cf.ac.uk/id/eprint/62669

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Cited 54 times in Web of Science. View in Web of Science.

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