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Garlic (Allium sativum) as an anti-Candida agent: a comparison of the efficacy of fresh garlic and freeze-dried extracts

Lemar, Katey M., Turner, M. P. and Lloyd, David 2002. Garlic (Allium sativum) as an anti-Candida agent: a comparison of the efficacy of fresh garlic and freeze-dried extracts. Journal of Applied Microbiology 93 (3) , pp. 398-405. 10.1046/j.1365-2672.2002.01707.x

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Abstract

Aims: To determine the effects of fresh and freeze-dried extracts of Allium sativum on the physiology and morphology of Candida albicans. Methods and Results: Inhibition of growth in glucose-yeast extract-peptone was measured using a multiwell plate reader. Scanning and transmission electron microscopy investigations indicated loss of structural integrity. Gas chromatography-mass spectrometry of extracts was employed to separate and quantify putative inhibitory sulphur-containing components. Conclusions: Fresh garlic extract has a greater efficacy than garlic powder extract as indicated both by its effects on morphology and inhibition of growth. Significance and Impact of the Study: The ubiquitous opportunistic pathogen C. albicans is sensitive to garlic; resistance to the broad spectrum of active principles present is unlikely so that its anticandidal effects may provide an important alternative route to chemotherapy.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Wiley-Blackwell
ISSN: 1364-5072
Last Modified: 04 Jun 2017 06:36
URI: http://orca.cf.ac.uk/id/eprint/62680

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