Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

A functional polymorphism in the promoter of monoamine oxidase A gene and bipolar affective disorder

Kirov, George, Norton, N., Jones, Ian Richard, McCandless, F., Craddock, Nicholas John and Owen, Michael John 1999. A functional polymorphism in the promoter of monoamine oxidase A gene and bipolar affective disorder. International Journal of Neuropsychopharmacology 2 (4) , pp. 293-298. 10.1017/s1461145799001601

Full text not available from this repository.

Abstract

The genes encoding for the enzymes monoamine oxidase (MAO) A and B are good candidates to investigate bipolar affective disorder. A 30 bp repeat in the MAOA promoter was recently demonstrated to be polymorphic and to affect transcriptional activity. In a family-based association design we found that none of the different repeat copies was preferentially transmitted from mothers (n = 131) to their children affected with bipolar disorder (chi(2) = 2.75, 4 d.f., p = 0.6). Following on our previous finding of an excess of low-activity genotypes of catechol-O-methyltransferase in patients with a rapid cycling form of illness, we examined for a similar trend with MAOA alleles. In an extended sample we found a non-significant trend for patients with an ultra-rapid cycling form of illness (n = 29) to have a higher frequency of low-activity alleles compared with 92 bipolar patients with a non-rapid cycling course of illness (chi(2) = 2.37, 1 d.f., p = 0.13).

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Additional Information: Grant Support G9810900/Medical Research Council/United Kingdom
Publisher: Cambridge University Press
ISSN: 1461-1457
Last Modified: 17 Apr 2019 20:46
URI: http://orca.cf.ac.uk/id/eprint/63048

Citation Data

Cited 27 times in Google Scholar. View in Google Scholar

Cited 23 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item