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Midbrain dopaminergic development in vivo and in vitro from embryonic stem cells

Maxwell, Sarah L. and Li, Meng 2005. Midbrain dopaminergic development in vivo and in vitro from embryonic stem cells. Journal of Anatomy 207 (3) , pp. 209-218. 10.1111/j.1469-7580.2005.00453.x

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Abstract

The midbrain dopaminergic (mDA) neurons play a key role in the function of a variety of brain systems, including motor control and reward pathways. This has led to much interest in these neurons as targets for intervention in human disorders such as Parkinson's disease and schizophrenia. A major area of interest is to direct embryonic stem (ES) cells to differentiate into mDA neurons in vitro, which can then be used for cell therapy or drug screening. At present, our understanding of mDA development in vivo is limited. However, recent studies have identified a number of regulatory factors that influence the development of mDA neurons in vivo. Such studies will not only increase our understanding of mDA development in vivo, they may also promote new paradigms for regulating mDA production from ES cells in vitro. Here we review the current knowledge on mDA development in vivo and mDA differentiation.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Medicine
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: Differentiation; dopaminergic neuron; embryonic stem cells; Pitx3; transcription factor.
Publisher: Wiley
ISSN: 0021-8782
Last Modified: 04 Jun 2017 06:38
URI: http://orca.cf.ac.uk/id/eprint/63101

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