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Adaptation ofDrosophilato a novel laboratory environment reveals temporally heterogeneous trajectories of selected alleles

Orozco-terWengel, Pablo, Kapun, Martin, Nolte, VIiola, Kofler, Robert, Flatt, Thomas and Schlotterer, Christian 2012. Adaptation ofDrosophilato a novel laboratory environment reveals temporally heterogeneous trajectories of selected alleles. Molecular Ecology 21 (20) , pp. 4931-4941. 10.1111/j.1365-294X.2012.05673.x

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Abstract

The genomic basis of adaptation to novel environments is a fundamental problem in evolutionary biology that has gained additional importance in the light of the recent global change discussion. Here, we combined laboratory natural selection (experimental evolution) in Drosophila melanogaster with genome-wide next generation sequencing of DNA pools (Pool-Seq) to identify alleles that are favourable in a novel laboratory environment and traced their trajectories during the adaptive process. Already after 15 generations, we identified a pronounced genomic response to selection, with almost 5000 single nucleotide polymorphisms (SNP; genome-wide false discovery rates < 0.005%) deviating from neutral expectation. Importantly, the evolutionary trajectories of the selected alleles were heterogeneous, with the alleles falling into two distinct classes: (i) alleles that continuously rise in frequency; and (ii) alleles that at first increase rapidly but whose frequencies then reach a plateau. Our data thus suggest that the genomic response to selection can involve a large number of selected SNPs that show unexpectedly complex evolutionary trajectories, possibly due to nonadditive effects.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Blackwell Publishing
ISSN: 0962-1083
Last Modified: 04 Jun 2017 06:39
URI: http://orca.cf.ac.uk/id/eprint/63262

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