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Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity

Han, Wenling, Lou, Yaxin, Tang, Junmin, Zhang, Yingmei, Chen, Yingyu, Li, Ying, Gu, Weifeng, Hueng, Jiaqiang, Gui, Liming, Tang, Yan, Li, Feng, Song, Quansheng, Di, Chunhui, Wang, Lu, Shi, Qun, Sun, Ronghua, Xia, Donglan, Rui, Min, Tang, Jian and Ma, Dalong 2001. Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity. Biochemical Journal 357 (1) , pp. 127-135. 10.1042/0264-6021:3570127

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Abstract

Cytokines are small proteins that have an essential role in the immune and inflammatory responses. The repertoire of cytokines is becoming diverse and expanding. Here we report the identification and characterization of a novel cytokine designated as chemokine-like factor 1 (CKLF1). The full-length cDNA of CKLF1 is 530bp long and a single open reading frame encoding 99 amino acid residues. CKLF1 bears no significant similarity to any other known cytokine in its amino acid sequence. Expression of CKLF1 can be partly inhibited by interleukin 10 in PHA-stimulated U937 cells. Recombinant CKLF1 is a potent chemoattractant for neutrophils, monocytes and lymphocytes; moreover, it can stimulate the proliferation of murine skeletal muscle cells. These results suggest that CKLF1 might have important roles in inflammation and in the regeneration of skeletal muscle.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
European Cancer Stem Cell Research Institute (ECSCRI)
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: Interleukin 10; skeletal-muscle cells; splicing; suppression–subtractive hybridization.
Publisher: Biochemical Society
ISSN: 0264-6021
Last Modified: 04 Jun 2017 06:39
URI: http://orca.cf.ac.uk/id/eprint/63365

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