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Effects of n-3 fatty acids on cartilage metabolism

Curtis, Clare Louise, Rees, Sarah G., Cramp, Joanna, Flannery, Carl R., Hughes, Clare Elizabeth, Little, Chris B., Williams, Rhys, Wilson, Chris, Dent, Colin M., Harwood, John L. and Caterson, Bruce 2002. Effects of n-3 fatty acids on cartilage metabolism. Proceedings of the Nutrition Society 61 (3) , pp. 381-389. 10.1079/PNS2002174

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Abstract

Although the clinical benefits of dietary supplementation with n-3 polyunsaturated fatty acids (PUFA) has been recognised for a number of years, the molecular mechanisms by which particular PUFA affect metabolism of cells within the synovial joint tissues are not understood. This study set out to investigate how n-3 PUFA and other classes of fatty acids affect both degradative and inflammatory aspects of metabolism of articular cartilage chondrocytes using an in vitro model of cartilage degradation. Using well-established culture models, cartilage explants from normal bovine and human osteoarthritic cartilage were supplemented with either n-3 or n-6 PUFA, and cultures were subsequently treated with interleukin 1 to initiate catabolic processes that mimic cartilage degradation in arthritis. Results show that supplementation specifically with n-3 PUFA, but not n-6 PUFA, causes a decrease in both degradative and inflammatory aspects of chondrocyte metabolism, whilst having no effect on the normal tissue homeostasis. Collectively, our data provide evidence supporting dietary supplementation of n-3 PUFA, which in turn may have a beneficial effect of slowing and reducing inflammation in the pathogenesis of degenerative joint diseases in man.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: n-3 PUFA; Cartilage metabolism; Chondrocytes; Degenerative diseases.
Additional Information: Joint National Nurses Nutritional Group and Parenteral and Enteral Group of the British Dietetic Association Symposium on ‘Working in Partnership’
Publisher: Cambridge University Press
ISSN: 0029-6651
Last Modified: 04 Jun 2017 06:39
URI: http://orca.cf.ac.uk/id/eprint/63377

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