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The role of transforming growth factor-β in atherosclerosis

Singh, Nishi N. and Ramji, Dipak Purshottam 2006. The role of transforming growth factor-β in atherosclerosis. Cytokine & Growth Factor Reviews 17 (6) , pp. 487-499. 10.1016/j.cytogfr.2006.09.002

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Abstract

Transforming growth factor-β (TGF-β) plays a pivotal role in a range of biological processes, including the control of cellular proliferation and differentiation, regulation of tissue repair and extracellular matrix accumulation, and modulation of the immune and inflammatory responses. The role of TGF-β in the pathogenesis of atherosclerosis, which is widely perceived as a form of chronic inflammation, has been the subject of debate for a number of years. A pro-atherogenic role was suspected because of its ability to promote fibrosis and to inhibit endothelial regeneration. However, several recent studies have shown that TGF-β limits atherosclerosis by modulating a number of processes, including the accumulation of lipids in the vessel wall and the inflammatory response. This review will discuss the role of TGF-β in atherosclerosis along with the molecular mechanisms underlying its action during the pathogenesis of the disease.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: Atherosclerosis; Gene regulation; Inflammation; Signal transduction; Transforming growth factor-β.
Publisher: Elsevier
ISSN: 1359-6101
Last Modified: 04 Jun 2017 06:40
URI: http://orca.cf.ac.uk/id/eprint/63439

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