McLarnon, Stuart J. and Riccardi, Daniela ORCID: https://orcid.org/0000-0002-7322-3163 2002. Physiological and pharmacological agonists of the extracellular Ca2+-sensing receptor. European Journal of Pharmacology 447 (2-3) , pp. 271-278. 10.1016/S0014-2999(02)01849-6 |
Abstract
Extracellular Ca2+ concentration [Ca2+]o is vital for a number of processes varying from blood clotting to regulation membrane permeability and excitability. For this reason [Ca2+]o is under strict control of a complex homeostatic system that includes parathyroid glands, kidneys, bones and intestine. The extracellular Ca2+-sensing receptor is an essential component of this system, regulating parathyroid hormone secretion, Ca2+ (and Mg2+) excretion by the kidney, bone remodeling and Ca2+ reabsorption by the gastrointestinal tract. The Ca2+-sensing receptor is also present in organs without an obvious link with mineral ion metabolism. This review will describe the discovery of a novel class of ion-sensing receptor(s), receptor–effector coupling and the roles of the Ca2+-sensing receptor inside and outside the Ca2+o homeostatic system.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Biosciences |
Publisher: | Elsevier |
ISSN: | 0014-2999 |
Last Modified: | 27 Oct 2022 08:49 |
URI: | https://orca.cardiff.ac.uk/id/eprint/63471 |
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