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Linkage studies of bipolar disorder in the region of the Darier's disease gene on chromosome 12q23-24.1

Dawson, E., Parfitt, E., Roberts, Q., Daniels, J., Lim, L., Sham, P., Nothen, M., Propping, P., Lanczik, M., Maier, W., Reuner, U., Weissenbach, J., Gill, M., Powell, J., McGuffin, P., Owen, Michael John and Craddock, Nicholas John 1995. Linkage studies of bipolar disorder in the region of the Darier's disease gene on chromosome 12q23-24.1. American Journal of Medical Genetics 60 (2) , pp. 94-102. 10.1002/ajmg.1320600203

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We have recently described a family in which there is cosegregation of major affective disorder with Darier's disease and have mapped this autosomal dominant skin disorder to 12q23-q24.1. This has provided an interesting candidate region for genetic studies of bipolar disorder. We have studied the segregation of seven markers spanning the Darier's disease locus in 45 bipolar disorder pedigrees and found modest evidence in support of linkage under heterogeneity for 5 of these markers. Nonparametric analyses were suggestive of linkage with a marker at the gene encoding a secretory form of phospholipase A2. Our sample has relatively low power to detect linkage under heterogeneity and independent researchers should examine markers from this region in further samples of bipolar pedigrees.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Publisher: Wiley
ISSN: 0148-7299
Last Modified: 17 Apr 2019 20:58

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