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Familial cosegregation of major affective disorder and Darier's disease (keratosis follicularis)

Craddock, Nicholas John, Owen, Michael John, Burge, S., Kurian, B., Thomas, P. and McGuffin, P. 1994. Familial cosegregation of major affective disorder and Darier's disease (keratosis follicularis). British Journal of Psychiatry 164 (3) , pp. 355-358. 10.1192/bjp.164.3.355

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Darier's disease is a rare autosomal dominantly inherited keratosis. This is an account of one family in which there is co-occurrence of major affective disorder and Darier's disease in five members and absence of both disorders in five members. The pedigree is consistent with genetic linkage between the Darier gene and a major autosomal dominant susceptibility locus for major affective disorder. When the Darier's disease gene has been mapped, its chromosomal location will be an interesting candidate locus for linkage studies of major affective disorder.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Publisher: Royal College of Psychiatrists
ISSN: 0007-1250
Funders: Wellcome Trust
Last Modified: 17 Apr 2019 20:59

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