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The dopamine D3 receptor gene: no association with bipolar affective disorder

Shaikh, S., Ball, D., Craddock, Nicholas John, Castle, D., Hunt, N., Mant, R., Owen, Michael John, Collier, D. and Gill, M. 1993. The dopamine D3 receptor gene: no association with bipolar affective disorder. Journal of Medical Genetics 30 (4) , pp. 308-309. 10.1136/jmg.30.4.308

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Bipolar affective disorder and schizophrenia share many clinical and genetic characteristics, and are thought by some to be different expressions of the same underlying disorder. A recent study showed an excess of homozygosity at a BalI polymorphism in the dopamine D3 receptor gene in schizophrenic patients compared with controls, from two independent centres. We have found no evidence of such an excess in a comparable sample of patients with bipolar affective disorder compared with matched controls. If these findings are confirmed then at least one genetic distinction between these two disorders will have been ascertained and doubt cast upon theories of a common genetic aetiology.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Publisher: BMJ Publishing Group
ISSN: 1468-6244
Last Modified: 17 Apr 2019 20:59

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