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Determinant spreading and the dynamics of the autoimmune T-cell repertoire [review]

Lehmann, P. V., Sercarz, E. E., Forsthuber, T., Dayan, Colin Mark and Gammon, G. 1993. Determinant spreading and the dynamics of the autoimmune T-cell repertoire [review]. Immunology Today 14 (5) , pp. 203-208. 10.1016/0167-5699(93)90163-f

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Abstract

In this article the authors propose a dynamic model of autoimmunity with T-cell recruitment and selection leading to changes in the specificity of the anti-self response during the course of disease. They argue that these changes are due to alterations in self-antigen presentation that lead to the display of previously cryptic self-determinants. Mechanisms that could underlie this differential self-presentation are proposed.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier
ISSN: 0167-5699
Last Modified: 04 Jun 2017 06:41
URI: http://orca.cf.ac.uk/id/eprint/63681

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