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A distinct member of the aspartic proteinase gene family from the human malaria parasite Plasmodium falciparum

Berry, Colin, Humphreys, Michelle J., Matharu, Philip, Granger, Rachel, Horrocks, Paul, Moon, Richard P., Certa, Uli, Ridley, Robert G., Bur, Daniel and Kay, John 1999. A distinct member of the aspartic proteinase gene family from the human malaria parasite Plasmodium falciparum. FEBS Letters 447 (2-3) , pp. 149-154. 10.1016/S0014-5793(99)00276-8

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Abstract

A gene (hap) transcribed during the intra-erythrocytic life cycle stages of the human malaria parasite Plasmodium falciparum was cloned and sequenced. It was found to encode a protein belonging to the aspartic proteinase family but which carried replacements of catalytically crucial residues in the hallmark sequences contributing to the active site of this type of proteinase. Consideration is given as to whether this protein is the first known parasite equivalent of the pregnancy-associated glycoproteins that have been documented in ungulate mammals. Alternatively, it may be operative as a new type of proteinase with a distinct catalytic mechanism. In this event, since no counterpart is known to exist in humans, it affords an attractive potential target against which to develop new anti-malarial drugs.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QR Microbiology
Uncontrolled Keywords: Malaria; Aspartic proteinase; Plasmodium
Publisher: Elsevier
ISSN: 0014-5793
Last Modified: 20 Dec 2017 01:53
URI: http://orca.cf.ac.uk/id/eprint/64826

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