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Synucleins: to have or not to have?

Ninkina, Natalia and Buchman, Vladimir L. 2000. Synucleins: to have or not to have? Russian Journal of Genetics 36 (11) , pp. 1487-1491.

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Abstract

Synucleins, a protein family little known even three years ago, became extremely popular after two discoveries. First, alpha-synuclein was found to be involved in etiology and pathogenesis of neurodegenerative disorders. Second, some newly discovered synucleins were found to participate in development and function of certain divisions of the nervous system and some other tissues, as well as in malignisation of breast tumors. It is now evident that synucleins are a fundamentally new group of proteins. Despite the striking similarity of their amino-acid sequences, they have diverse and multiple functions. An important challenge for biomedical science is to understand functions of sinucleins in normal cells and their role in pathology.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QH Natural history > QH301 Biology
Language other than English: Russian
Publisher: Springer Verlag
ISSN: 1022-7954
Last Modified: 18 Nov 2018 22:04
URI: http://orca.cf.ac.uk/id/eprint/65107

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