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Inhibition of a receptor-operated calcium channel in pig aortic microsomes by cyclic GMP-dependent protein kinase

Blayney, Lynda Mary, Gapper, Peter William James and Newby, Andrew C. 1991. Inhibition of a receptor-operated calcium channel in pig aortic microsomes by cyclic GMP-dependent protein kinase. Biochemical Journal 273 (3) , pp. 803-806.

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Abstract

We have further characterized a putative receptor-operated Ca21 channel that is activated by histamine and guanosine 5'-[/ly-imido]triphosphate. Insensitivity to verapamil, diltiazem or nicardipine, but inhibition by Ni2+ and SK&F 96365, further identify the channel with receptor-mediated Ca2+ entry in intact cells. Inhibition of the channel by cyclic-GMPdependent protein kinase may contribute to vascular relaxation in response to nitrovasodilators.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Portland Press
ISSN: 0264-6021
Related URLs:
Last Modified: 31 Jan 2020 04:19
URI: http://orca.cf.ac.uk/id/eprint/65161

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