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Characterization of a sea bream (Sparus aurata) thyroid hormone receptor-β clone expressed during embryonic and larval development

Nowell, M. A., Power, D. M., Canario, A. V. M., Llewellyn, L. and Sweeney, Glen E. 2001. Characterization of a sea bream (Sparus aurata) thyroid hormone receptor-β clone expressed during embryonic and larval development. General and Comparative Endocrinology 123 (1) , pp. 80-89. 10.1006/gcen.2001.7649

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Abstract

Sparus aurata) ovary cDNA library. Sea bream (sb)TR-β is closely related to its counterparts from other vertebrates and, like them, preferentially binds T3 rather than T4. However, the putative sbTR-β protein contains a nine-amino-acid insert that is also present in the corresponding proteins from flounder and salmon but absent in TR-βs from zebrafish and terrestrial vertebrates. Semiquantitative RT–PCR analysis showed that sbTR-β transcripts begin to accumulate during gastrulation and increase markedly in quantity up to the period around hatch (ca. 40 h postfertilization) before declining slightly. In adult tissues, TR-β mRNA was present in approximately equal quantities in heart, intestine, brain, kidney, skeletal muscle, liver, and gill. The significance of the relatively strong expression of TR-β during sea bream embryogenesis is discussed.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Elsevier
ISSN: 0016-6480
Last Modified: 02 May 2019 10:59
URI: http://orca.cf.ac.uk/id/eprint/65591

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Cited 30 times in Web of Science. View in Web of Science.

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