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Cloning and sequencing of a COUP transcription factor gene expressed in Xenopus embryos

Matharu, Philip J. and Sweeney, Glen E. 1992. Cloning and sequencing of a COUP transcription factor gene expressed in Xenopus embryos. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1129 (3) , pp. 331-334. 10.1016/0167-4781(92)90512-X

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Abstract

A cDNA clone encoding COUP transcription factor, a member of the steroid/thyroid receptor superfamily, has been isolated from a Xenopus neurula (stage 17 embryo) library. Sequencing of this clone reveals an open reading frame encoding a 397 amino acid protein. The amino acid sequence of Xenopus COUP has been compared with its human and Drosophila homologues showing that there are few similarities within the amino-terminal region, whereas the remainder of the protein, including the putative DNA and ligand binding domains, is very well conserved.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Elsevier
ISSN: 0167-4781
Last Modified: 02 May 2019 11:01
URI: http://orca.cf.ac.uk/id/eprint/65603

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